Colorectal cancer CRC is the third most common neoplasm, and its prevalence increases with age and with social and economic status urbanization. Studies have shown an increased risk of cancer in DM patients, especially along the digestive tract, including CRC, without being able to find a clear pathogenic link between the two chronic diseases.
In this review we intend to analyze the relationship between DM and CRC in terms of epidemiology and risk factors. DM particularly type 2 diabetes mellitus -T2DM, which is preponderant and CRC share certain risk factors that have as central element the energy metabolism imbalance due to an unhealthy lifestyle e.
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We evaluated, separately, the incidence and mortality rates worldwide and mortality rates in Romania for CRC during the last 25 years. For DM we evaluated its prevalence worldwide during the last 20 years.
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Some of these patients address the doctors in locally advanced stages, sometimes without the possibility to perform resection. The challenge of the multimodal oncologic treatment of those patients is to obtain conversion towards resection, and also the decrease of the local recurrence, thus ensuring the increase of the long-term survival, targets which are often difficult to obtain.