Unfortunately, it does not have specific signs and symptoms, being associated with an aggressive evolution and a poor prognosis if left untreated. Their results suggest that PD-1 and PD-L1 could be potential biomarkers for targeted treatment in some patients diagnosed with diffuse large B-cell lymphoma.
Malignant lymphomas of familial cancer syndrome database head and neck may raise therapeutic difficulties. OIU, Vlad D. In the last five years from 1st of January to 31st of Decemberwe noticed 6 cases of rectal cancer, developed in patients who underwent stoma reversal more than two years before, for different pathologies.
The objective of the study. That was a starting point to analyze whether the restoration of a total digestive diversion, well known to improve life quality, also increases the risk of malignancy.
Material and methods. Our study showed that stoma reversal increase the risk of developing a rectal malignancy two years from restoration. We recommend annual control by recto-sigmoidoscopy both in patients with terminal permanent colostomy and in those with stoma reversal, in order to early discover a subsequent rectal cancer. PD-L1 expression most often correlates with familial cancer syndrome database poor prognosis and a PD-1 regulatory factor that mediates immunosuppression.
The objective of this study was to describe the correlation between PD-1 and PDL-1 with survival in patients with the diagnosis of diffuse large B cell lymphoma.
We found that there is a tendency of decreased survival and therapeutic response in DLBCL patients, with both an intense and weak PD-L1 positivity in tumor cells. PD-1 low positivity was associated in higher percentage with relapse and treatment unresponsiveness.
Conclusions: Our data suggested that PD-L1 expression correlates with a poor clinical response although it is not an independent prognostic marker and PD-1 represents a favorable prediction factor for survival. Drug therapy in autoimmune thyroiditis Author : Michael I. Autoimmune thyroiditis AIT is one of the unsolved problems of modern endocrinology, the etiology and pathogenesis being still insufficiently known.
To study the effects of substitution, antioxidant and lymph-drainage therapy on the structure and function of the thyroid gland in patients with AIT and hypothyroidism. We have identified 2 groups of patients with AIT and subclinical hypothyroidism. The first group — control group — included 20 patients who received substitution therapy with thyroxine. The second group included 33 patients who received a comprehensive treatment with thyroxine, alpha lipoic acid and Lymphomyosot.
The use of substitution therapy with thyroxine and the proposed antioxidant and lymph drainage therapy in patients with AIT led to the improvement of the structure of the gland, reduced the activity of peroxide oxidation processes and the activity of pro-inflammatory cytokines, increased the level of antioxidant defense enzymes, normalized the number of aniline-positive lymphocytes, improved the lymphatic drainage function of the gland. Our results sustain the effectiveness of the proposed method of complex treatment in patients with autoimmune thyroiditis.
Ghrelin level and types of eating behavior o conspirație parazitară împotriva umanității combined with irritable bowel syndrome, arterial hypertension and obesity Author : Vasyl G.
However, its cardioprotective effect, as well as vasodilatory action and participation in arterial pressure regulation, are not sufficiently studied. To study fasting and postprandial ghrelin levels and eating behavior in patients with comorbidities such as irritable bowel familial cancer syndrome database, arterial hypertension, and obesity.
Materials and methods. The study included 24 patients with irritable bowel syndrome, constipation and normal body mass index, 18 patients with arterial hypertension and obesity, and 54 patients with irritable bowel syndrome, familial cancer syndrome database, familial cancer syndrome database hypertension, and obesity.
Blood pressure monitoring was performed in all patients and fasting and postprandial ghrelin levels in blood serum were measured, as cancer mamar bilateral as eating behavior type, using the Dutch Eating Behavior Questionnaire. Results of hour blood familial cancer syndrome database monitoring showed a more significant rise in blood pressure, as well as a predominance of the non-dipper profile, encountered in The increased level of postprandial serum ghrelin in patients with this comorbid pathology contributes to the predominance ofexternal and emotional types of eating behavior, which were found in The studied combined pathology irritable bowel syndrome with constipation, arterial hypertension, and obesity is accompanied by higher blood pressure, non-dipper blood pressure profile predominance, increased postprandial ghrelin level and eating disorders.
High-grade serous carcinoma of the ovary is an aggressive form of cancer, with unknown precursor lesions and often delayed diagnosis because of non-specific, mild symptoms. We performed a clinical-pathological study of ovarian high-grade serous carcinomas, in familial cancer syndrome database to evaluate morphological and new immunohistochemistry characteristics of this malignancy.
This is a retrospective study of 10 cases of ovarian high-grade serous carcinoma. Mean age was Maximum tumor diameter was 16 cm. We noticed one case with pleural metastasis M1.
The majority of patients with ovarian high-grade serous carcinomas presented with extraovarian extension familial cancer syndrome database were characterized by high mitotic index, rare presence of psammoma bodies, AR expression Bilateral breast carcinoma — a study of patients admitted in a university emergency hospital Author : Oana C.
Breast carcinoma represents the leading cause of oncologic mortality among women worldwide. Bilateral breast carcinoma is a distinct pathologic entity, with particular prognostic and therapeutic implications. The objective of the study was to determine the histologic and immunohistochemical characteristics of patients with bilateral breast carcinoma admitted in a university emergency hospital from Bucharest, Romania.
We analyzed breast carcinoma specimens registered as bilateral in the Department of Pathology of the University Emergency Hospital, Bucharest, Romania, betweenand studied their histologic and molecular features in the clinical context obtained from our hospital database. All the analyzed patients were postmenopausal women. The extent of time familial cancer syndrome database the diagnosis of the first and familial cancer syndrome database tumor varied in metachronous cases from 8 months to 7 years.
In the majority of cases, the bilateral breast lesions shared histologic, grading and hormone expression similarities. Bilateral breast carcinoma is a rare entity that needs more histologic parameters to be defined as primary or metastatic.
The purpose of the study was to determine whether the following 4 factors: age, sex, type of intervention and type of dialysis acute or chronichave an influence on the number of dialysis sessions associated with urological interventions.
The study included almost patients undergoing dialysis, during a 3 year period, in 3 university hospitals in Bucharest, Romania.
In the end, after applying the inclusion and exclusion criteria, the study group consisted of 89 patients. The time frame in which the number of dialysis sessions was evaluated started from the moment the patients entered urological surveillance for undergoing a urological intervention until the patients where discharged.
Familial cancer meaning. Familial cancer meaning, Translation of "cancer de colon" in English
Out of the 4 factors, the following statistically significant differences were encountered: the mean number of dialysis sessions was lower in patients under 50 years than in those older than 69 years p InterleukinA and Interleukin level in the blood serum of patients with different clinical course of Rosacea Author : Maryna V.
Rosacea is a common chronic dermatosis characterized by lesions of open areas of the skin face and torpidity to treatment. The objective of our study was to determine and analyze the content of proinflammatory cytokines — interleukinA ILA and interleukin IL in the serum of patients with rosacea, depending on the nature of the clinical course of dermatosis.
The study involved 36 patients with rosacea, 17 of them diagnosed with erythema-telangiectatic form and 19 with papulo-pustular form of rosacea.
In 18 patients, the dermatosis lasted for up to 6 months, in the remaining 18 patients for more than 6 months. In patients with rosacea, the serum content of individual cytokines, interleukinA and interleukin was determined by the immunoassay assay. It has been established that the content of proinflammatory familial cancer syndrome database in the serum of patients with rosacea is reliably elevated compared to that in the control group — ILA 4.
Lichen ruber planus LRP is a chronic multifactorial dermatosis characterized by skin deterioration, intensive itchiness, familial cancer syndrome database resistance to therapy. It leads to long term patient disability, therefore the main familial cancer syndrome database of the management is to define the pathogenetic factors of LRP, with the purpose of treatment optimization.
The benefits are certain in some cases: life years gained for those with curable disease, avoidance of morbidity, reassurance that the disease is at a very early stage, avoiding expenses of treatment for advanced cancers and extra years of productivity. But screening tests also have disadvantages, so a balanced decision must be made, with the help of clinical randomized trials. In this article I will present the current methods for screening accepted for general population and particular screening reserved for persons at high risk. Although in the first case the benefit is proven, the use of these methods in practice varies largely due to lack of resources and well designed health programs. Beneficiile sunt evidente în anumite cazuri: prelungirea supravieţuieii la cei cu familial cancer syndrome database curabilă, scăderea morbidităţii, asigurarea pacientului că boala se află în stadiu incipient, evitarea costurilor crescute asociate cu tratamentul formelor avansate de boală şi creşterea numărului de ani de productivitate.
The objective of this study was to determine and familial cancer syndrome database the level of individual cytokines in blood serum of patients with lichen ruber planus with different clinical symptoms of dermatosis. The study involved 37 patients with lichen ruber planus. In 20 patients with LRP the pathology of the skin was widespread, and in 17 patients it was limited and localized.
In 19 patients the dermatosis lasted for up to 6 months, in the remaining 18 patients — for more than 6 months. Significant changes in the content of the cytokines in the blood serum were observed for the patients with a widespread form of lichen ruber planus and the duration of the disease for more than 6 months, comparing to those with limited forms of the dermatosis and duration of the disease for up to 6 months.
In patients with LRP, changes of the indicators of cytokine profile in the peripheral blood were observed. There was a significant increase in the level of proinflammatory cytokines TNF-a, IL-1ßand only a a mild increase or the tendency to decrease in the levels of anti-inflammatory cytokines IL-4 and IL, respectively. The magnitude of familial cancer syndrome database changes of cytokines was dependent on the nature of the clinical progression of the LRP.
This finding indicates the significance of the cytokines in the regulation of inflammatory processes in the pathogenesis of LRP.
These findings report the importance in examining levels of pro- and anti-inflammatory cytokines, as a criteria in the clinical evaluation of LRP and the effectiveness of its treatment. Ultrasonographic indices of skin changes in children with Helicobacter pylori-associated gastroduodenitis combined with food allergy Author : Tamila V.
To date, there are no early diagnostic criteria for skin familial cancer syndrome database in children with combined pathology of the gastrointestinal tract and food sensitization. To determine the ultrasound parameters of skin changes in children with Helicobacter pylori-associated chronic gastroduodenitis CGD combined with food allergy Papillomavirus biopsie. Skin ultrasound was performed by ultrasound scanners with linear sensors, with variable frequency, 3.
Average values are given in the form M ± mwhere M is the mean value of the index, m is the standard error of the mean, n — the volume of the analyzed group. In the acute period, children with H.
jurnalul de chirurgie journal of surgery - ISSN:
In the subacute period, the ultrasonographic skin changes in the affected children faded and were less pronounced in remission. The peculiarity of the ultrasound structure of the skin in familial cancer syndrome database with H-pylori-associated CGD in combination with FA is a pronounced thickening of all its layers, the presence of a hypoechoic strip in the superficial layer of the dermis and the strengthening of intradermal and subcutaneous arterial and venous blood flow.
Focal liver lesions represent one of the main indications of ultrasound-guided liver biopsy.
The purpose of the study was to evaluate the advantages and risks of liver biopsy, and to highlight the importance of a close follow-up in the prevention of postprocedural complications. We have retrospectively analyzed a number of 52 patients, who underwent liver biopsies in the Clinical Emergency Hospital of Bucharest, Romania, after being diagnosed with various types of focal liver lesions through ultrasound scanning.
This last category included hepatic adenomas and focal nodular hyperplasia, identified in young female population. There was no case of death registered. Ultrasound guided percutaneous liver biopsy is a fast, economical and user-friendly procedure, frequently used in the diagnosis of focal liver lesions.
The success rate of the biopsy in obtaining viable samples is high and it depends more on the structure familial cancer syndrome database the lesion and the materials used, rather than on the anatomical localization of the lesion within the liver. Severe complications can be avoided if a close follow-up of the patients familial cancer syndrome database performed. Male sex and tumor diameter are independent risk factors for relapse or persistent disease in differentiated thyroid cancer Author : Aysun S.
Differentiated thyroid cancer DTC is one of the most frequently observed neoplasms today. Recurrence of DTC has been previously reported to be dependent on tumor characteristics, the tumor size, the presence of lymph node metastasis, the presence of extra thyroid invasion, the presence of distant metastasis, oncogenes such as B-RAF proto-oncogene, advanced age and male sex.
However, many studies have failed to associate many of these data with relapse. In this study, we aimed to evaluate the relationship between some histopathological and morphological findings with thyroid cancer relapse or persistent disease in a cohort of DTC patients. We retrospectively analyzed subjects with DTC, diagnosed in our institution between January and December Histopathological analysis indicated papillary carcinoma in Eighty-two Male subjects had a higher trend for relapse RR 1.
Matériels et méthodes. Le groupe avec SM se composait de patients diagnostiqués selon les critères harmonisés.
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- Informaţii pentru pacienţi şi familiile lor Riscul de cancer familial cancer syndrome database san: Cancerul pancreatic This type of cancer has a high mortality, and the overall survival is also low.
La pression différentielle, les valeurs calculées pour les patients atteints de syndrome métabolique ont été généralement plus élevées que le taux moyen escompté à 40 mmHg, avec une valeur moyenne de 47,86 ± 12,02 mmHg.
Le groupe de contrôle a une valeur moyenne 40,28 ± Polytrauma patients represent one of the most difficult pathology. Therefore, developing methods of assessing the risk of death in these patients is a continuous challenge for physicians. The aim of the study was to evaluate the levels of creatine kinase isoenzyme MB CK-MB and troponin, as markers of increased risk of death in the first 24 hours after admission, in polytrauma patients with associated chest trauma.
The study included 33 polytrauma patients treated in the Emergency Department of the County Clinical Emergency Hospital Constanta, Romania, between In all these patients, clinical evaluation and paraclinical investigations have been performed, including measurements of CK-MB levels. The results of our study suggest that troponin values may be useful in identifying the increased risk of death in polytrauma patients.
Clinical-anamnestic peculiarities of the course of neonatal sepsis in newborns Author : Olena V. A retrospective analysis of medical records of newborns with neonatal sepsis, born in Chernivtsi maternity hospitals, Ukraine, during has been carried out. Among infants with neonatal sepsis, premature newborns from mothers with probable risk factors for the development of generalized bacterial infection prevailed. The disease was characterized by the symptoms of multiple organ failure, with a predominant defeat of the familial cancer syndrome database system, hemodynamics disorders, changes in the neurological status, and a decrease in food tolerance.
According to the results of bacteriological cultures of blood, the predominance of microorganisms association familial cancer syndrome database established, the leading place among them belonged to Klebsiella pneumoniae.
Laryngomalacia in infants Abstract Full Text Abstract : Laryngomalacia is a disease that is the most common etiology causing stridor in infants and in most cases the patient presents with inspiratory stridor that worsens during familial cancer syndrome database, crying, supine position or agitation.
In laryngomalacia the supraglottic structures collapse into the airway during inspiration causing airway obstruction. Typical symptoms are not present at birth, but appear within the first 4 months of life and disappear at maximum 24 months of age.
The most common associated symptoms are swallowing dysfunctions, regurgitation, cough and sleep apnea. A manual therapy approach to the neck familial cancer syndrome database due to abnormal head position Author : Marius S. Neck pain NP is an increasingly common symptom among the general population, regardless of age, but predominantly in women.
Most studies confirm the direct links between this symptom and the biomechanical changes in the cervical spine, induced by postural problems.
Cancer genetic disease
To identify the mechanisms of maintaining the cervical symptoms in patients with abnormal head position, as well as the benefits and limitations of manual therapy for these dysfunctions and also to suggest and develop complementary or substitutive solutions to the used therapies.
Removing the extra vertebral factors that cause head position changes and implicitly NP, followed by cranio-cervical-mandibular manual therapy, results in significant improvement in the postural syndrome and the reduction of the painful symptoms. It is characterized by the triad of abnormal arterial oxygenation caused by intrapulmonary vascular dilatations IPVD in the setting of advanced liver disease, portal hypertension, or congenital portosystemic shunts.
Liver transplantation is the only curative option for HPS. Pulmonary vascular dilation and angiogenesis are two central pathogenic features that cause abnormal pulmonary gas exchange in experimental HPS, and thus might underlie HPS in humans. The vascular component includes diffuse or local dilation of the pulmonary familial cancer syndrome database, and less commonly includes pulmonary arteriovenous shunts.
The mechanisms responsible for the vascular changes in HPS remain incompletely understood. Emerging evidence suggests that dietary patterns play a more significant role than the nutrients in CKD. The capsule endoscopy is the state-of-the-art, non-invasive procedure, providing a fine diagnosis of intestinal lesions, especially those found in the small bowel, difficult to address by other methods. Many studies have been published during the past years regarding the sensibility and outcome of capsule endoscopy in patients with gastrointestinal bleeding, but few underline its definitive papillomavirus homme consequence in the diagnosis of digestive bleeding.
This review looks at the role of capsule endoscopy in the evaluation of patients with gastrointestinal bleeding tratament pt paraziti the small bowel and the therapeutic options available. A thorough review of the literature was made using the PubMed database.
Sarcomas of the kidney are very rare malignant familial cancer syndrome database, with a very poor prognosis compared with the other urogenital sarcomas. Familial cancer syndrome database histological types have been reported, with the most common type being leiomyosarcoma.
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Besides complete surgical resection with wide margins, anatomical, histological, molecular and genetic factors should be taken into consideration regarding the prognosis.